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Phentermine is a drug that suppresses appetite and its exact mechanism of action is unknown. It probably minimizes appetite by acting on centers in the brain that control appetite. Phentermine is similar to amphetamine and it stimulates the nervous system, elevates blood pressure, and increases heart rate.
Phentermine medication should be stored in a tight container at room temperature.
Phentermine is combined with diet and exercise for the short-term treatment of obesity in individuals with a body mass index greater than or equal to 30 kg/m2 or more than or equal to 27 kg/m2 with risk factors for heart disease. Phentermine should not be taken with other weight loss agents. The combination of phentermine and fenfluramine is associated with serious heart problems. Fenfluramine drug is no longer available in the United States.
The recommended dose is 30 mg once daily about 2 hours after breakfast and evening doses should be avoided because phentermine causes insomnia.
Phentermine is mechanism of action is similar to amphetamine and may share some of the interactions associated with amphetamines. Combining phentermine with tricyclic antidepressants or monoamine oxidase inhibitors may result in high blood pressure and other serious reactions because of elevated serotonin levels in the blood. Use of phentermine during pregnancy has not been adequately evaluated and it is not known whether phentermine is excreted in human breast milk.
The adverse effects of phentermine include nausea, vomiting, diarrhea, dry mouth, constipation, an unpleasant taste, hives, impotence, palpitations, high blood pressure, and fast heart rates.. Central nervous system adverse effects include hyperactivity, insomnia, restlessness, tremor, and dizziness. Phentermine, especially when taken in combination with fenfluramine, has been associated with high pressures in the pulmonary arteries and defects in heart valves, both serious complications. Physical and psychological dependence may occur with the long-term use of this drug. A withdrawal reaction, which includes excessive drowsiness, fatigue, tremors and depression may occur after long-term use.